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serotonin theory of depression torpedoed

Posted by TriedEveryMedication on July 29, 2022, at 23:24:43

Large meta-analysis of 17 studies with over 150,000 subjects:

https://www.nature.com/articles/s41380-022-01661-0

"The two largest and highest quality studies of the SERT gene, one genetic association study (n = 115,257) and one collaborative meta-analysis (n = 43,165), revealed no evidence of an association with depression, or of an interaction between genotype, stress and depression. The main areas of serotonin research provide no consistent evidence of there being an association between serotonin and depression, and no support for the hypothesis that depression is caused by lowered serotonin activity or concentrations."


"Our comprehensive review of the major strands of research on serotonin shows there is no convincing evidence that depression is associated with, or caused by, lower serotonin concentrations or activity. Most studies found no evidence of reduced serotonin activity in people with depression compared to people without, and methods to reduce serotonin availability using tryptophan depletion do not consistently lower mood in volunteers."


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poster:TriedEveryMedication thread:1120172
URL: http://www.dr-bob.org/babble/20220530/msgs/1120172.html