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Re: IV Ketamine, not nasal spray

Posted by SLS on July 9, 2019, at 9:47:37

In reply to Re: IV Ketamine, not nasal spray, posted by SLS on July 6, 2019, at 22:47:58

> Have you heard anything about hydroxynorketamine (HNK)? It is a metabolite of ketamine that can be given orally. It is not supposed to have psychotomimetic or dissociative side effects.

After poking around a little, I am left with the impression that HNK is not as effective as ketamine, even though it raises BDNF levels, increases mTOR signaling, and promotes neuroplasticity in rats. I would still like to see well-controlled human trials. I don't think there are any.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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