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Does anyone know how to activate Trk-B?

Posted by SLS on February 9, 2019, at 13:16:56

Hi.

Linkadge has been interested in Trk-B for a long time. Trk is the abbreviation for tropomyosin receptor kinase. Blocking this receptor is how most current biologics work when treating autoimmune diseases. However, activating this receptor might act to improve depression. One study of rodents found that all of the antidepressants they tested increased Trk-B. The authors suggested that perhaps this a common thread linking the different classes of antidepressants. Apparently, BDNF is not necessary for this effect on Trk-B.


- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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URL: http://www.dr-bob.org/babble/20190206/msgs/1103177.html