Posted by porkpiehat on January 15, 2019, at 14:06:50
In reply to Re: How can ADs increasing norepinephrine help anxiety » bleauberry, posted by Hordak on January 14, 2019, at 15:19:27
I've often wondered this myself...I'm under the impression that I tend to get more feelings of emotional detachment, sadness, zoning, and sedation on NE drugs. My theory is that, as someone suffering from complex trauma, the activation of the sympathetic nervous system creates a trauma response of total numbness and dysphoria, almost dissociation, occasionally Anger too.
Then the pro-focus part of the drug locks me into this feeling and removes me from positive or exciting stimuli. haven't gotten a doctor to seriously address this theory.
The following meds did this to me:
wellbutrin
Parnate
desipramine
Nortriptyline
Cymbalta
Effexor
Nardil
probably one or two others. I never gave the TCAs longer than a couple of days. Wellbutrin felt good for a week before turning on me and dissociating the f*ck out of me. Two days on cymbalta flipped me out and I tore into family members.Meds that reverse this tendency included prazosin, trileptal, gabapentin...
Your theory, which I hadn't considered, does make sense that the body would desensitize to NE eventually. That's why people take cymbalta for sweating and eventually get overly sedated I guess.
depending on the receptor, serotonin can have an aggitating, numbing effect on people too.
poster:porkpiehat
thread:1102698
URL: http://www.dr-bob.org/babble/20181024/msgs/1102800.html