Posted by Christ_empowered on May 19, 2018, at 6:15:20
In reply to new antidep/mood stabilizer with Parnate, posted by peanut2 on May 19, 2018, at 0:27:48
hi. way back when, there were combo pills with a bit of Stelazine+Parnate. It was sort of like a non-addictive goof ball...the Parnate helped the depression, the Stelazine controlled agitation, anxiety, etc. I mean...when it worked, without too many problems...
the data on the 'atypical' vs 'conventional' tranquilizers is kind of mixed, confusing. perphenazine did well in the CATIE study, in people with a diagnosis of Schizophrenia. Its not as high potency as Stelazine, so more sedation, less EPS, less akathisia, but its higher potency than Thorazine, so less sedation, fewer anticholinergic effects, etc. I just mention perphenazine because its cheap, generic, and doesn't have the same level of metabolic ill-effects as many "atypicals."
loxapine is another 'conventional' neuroleptic that, at low doses at least, seems to have comparable tolerability to 'atypials.' if the dose gets too high, though, its not that much different from taking Haldol.
my former shrink recommended amoxapine. i declined, but...I kind of wish I'd at least tried it. Its a tca antidepressant that is partly metabolized into loxapine. the end result is help w/ some forms of low mood, plus the tranquilizer component. limited data seems to show that -if- one responds to amoxapine, response comes more quickly than with other antidepressants, which lines up with what's been observed with 'atypical'+antidepressant combinations.
when you say you're depressed, what sort of problems does your depression include? stimulants were once fairly common with parnate. I don't know if many shrinks go for that now, though. Ivan Goldberg had a webpage way back when...he wrote about using dexedrine and desoxyn a good bit in people on Parnate.
if you think a neuroleptic might help, maybe one of the new D2 partial agonists? Rexulti is approved for depression, I think.
I hope this helps a bit. good luck.
poster:Christ_empowered
thread:1098755
URL: http://www.dr-bob.org/babble/20180331/msgs/1098756.html