Posted by bleauberry on April 21, 2018, at 8:37:20
In reply to TRIP8b inhibitors? Truly novel antidepressants., posted by SLS on April 21, 2018, at 6:31:42
I would just say that maybe another novel approach would be to identify the cause of the "times of stress" and fix that. Make it so we fix the actual problems so we don't need a protein manipulating drug.
I mean, I have a question. Our scientists are so brilliant that they can figure out how to manipulate various proteins this way or that way, but they can't figure out what is actually wrong with the person's chemistry?
Why do they focus on downstream but not upstream?
In any case, the medical world could use some new options in terms of psychiatric medications so hopefully these new discoveries will help to improve the quality of life for some folks.
> A novel set of antidepressant drugs might be developed that inhibit the actions of TRIP8b. This protein acts during times of stress to suppress activity in the hippocampus via the entorhinal cortex, which is located upstream. The hippocampus is a brain structure involved in mood and memory. When TRIP8b is inhibited, both of these regions become more active. In the laboratory, TRIP8b knock-out mice demonstrated antidepressant behavior and memory-enhancement. I couldn't guess at how long it would take for such compounds to become available - if at all. Some of us will never see them, but our children might.
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> - Scott
poster:bleauberry
thread:1098278
URL: http://www.dr-bob.org/babble/20180331/msgs/1098280.html