Posted by jonhed on July 25, 2016, at 16:37:46
In reply to anti-cholinergic = dyphoria, posted by rjlockhart37 on July 24, 2016, at 20:19:18
Yeah you get dysphoric form to much anti-cholinergics..
When i was on 8 milligrams of Biperiden to cope with the EPS that i got from perphenazine IM long acting, i was very anxious and "out of it".
Same with trihexyphenidyl, it will cause euphoria initially, but after a wile it causes dysphoria to..
The first link you shared is about Salvia Divinorum though, and that is a potent Kappa-opioid.
K-opioids are well known to be dysphoric, but they are also proven to be good for anxiety and there are a lot of substances in phase 3 that are targeting the Kappa-opioid receptor.It's a matter of balance i think.
Buprenorphine are a k-opioid agonist, and there is a drug under development that are buprenorphine/samidorphan and is going to be an adjunct for TRD, and that is a k-opioid agonist that are not that abusable as pure buprenorphine are cause samidorphan is blocking the MOR-receptor and u-opioid receptor, that equals no euphoria but more therapeutic useful.
So that is not black and white, dysphoria and euphoria are very much alike i would like to say.
Espacially when it is caused by a substance..Just my thought.
Kind regards
poster:jonhed
thread:1090835
URL: http://www.dr-bob.org/babble/20160713/msgs/1090860.html