Posted by linkadge on April 6, 2016, at 15:56:17
In reply to Re: replace zyprexa with what? » linkadge, posted by J Kelly on April 6, 2016, at 11:52:14
Some of the older antispychotics were unfairly villainized when newer (on patent) atypical antipsychotics came out.
There was a large study (named 'CATIE' I believe), suggested that newer atypicals were not any better at relieving positive or negative symptoms, and they were associated with higher rates of metabolic issues.
The older medications did have higher rates of TD, but lower rates of inducing metabolic complications.
Although perphenazine is an 'older' antipsychotic, it does have atypical actions in that it affects both serotonin and dopamine systems. It is relatively less potent, and hence can be obtained in weaker doses. I believe it blocks primarily 5-ht2a receptors, and 5-ht2c less so. This means that weight gain is likely not as prominent as it is with Zyprexa.
I mean, it is still an antipsychotic. It should not be used unless an antipsychotic is warranted, but perphenazine is not a bad alternative to try in place of newer atypicals.
Linkadge
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thread:1087856
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