Posted by busub on June 16, 2015, at 14:34:22
In reply to Re: Desipramine Questions » busub, posted by SLS on June 16, 2015, at 14:16:12
I've tried both Effexor and Cymbalta.
I had the same activation issues with Effexor and couldn't get past 112.5mg/day, so I wasn't even getting any NRI action from that dose. That was an 8 week trial.
I later had a Cymbalta trial for 12 weeks and was constantly in a drowsy haze with some weird activation thrown in.
The following is what I've trialed, in order:
Paroxetine (50mg worked for 18 months, mild activation, tapered off, reinstated, didn't work again)
Sertraline (150mg worked for 12 months, never completely rid of restlessness, then started getting terrible akathisia)
Escitalopram (20mg 6 months, incomplete remission, tried augmentation with Lamictal then Elavil to ease activation)
Venlafaxine (112.5mg 2 months)
Clomipramine (75mg 3 months)
Fluoxetine (10mg 3 months, activating effects never went away)
Duloxetine (60mg 3 months, tried augmenting with burpropion for energy, but too activating)
Vortioxetine (20mg 2 months, chest pain and anger)Citalopram (20 mg6 months, anhedonia, incomplete response, activation)
Mirtazapine (45mg 2 months, sedation, hunger, angry)
Pregabalin (50mg bid 2 weeks, increased depression)
Lurasidone (20mg?? 1 week, akathisia and dystonia in the form of muscle cramping)
DesipramineMy initial diagnosis was GAD, but has since morphed into Dysthymia. My biggest issue with meds is that they all cause this background activation that was tolerable only for paroxetine and sertraline. Ever since it's been unbearable or came with other side effects that made things unbearable when combined. I feel like I'm at my wits end trying to get this sh*t under control and I don't know what to do.
poster:busub
thread:1079697
URL: http://www.dr-bob.org/babble/20150520/msgs/1079801.html