Posted by SLS on March 25, 2015, at 0:04:57
In reply to Re: Discouraged after reading book on resistant cases » Robert_Burton_1621, posted by Deahoidar on March 24, 2015, at 14:32:40
What site in the brain did your DBS target?
I am not familiar with the ventral capsule/striatum being a target of DBS historically for depression. I have seen Brodmann' Area 25 and the nucleus accumbens targeted. I would like to see a RCT of DBS at these sites.
- Scott
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> > > I have a considerable library on the subject.
> >
> > Deahoidar. I'm sorry to hear of your unfortunate, and (it seems) clinically brutal, experience with DBS. I am very interested in reading any citations to research you may be minded to share.
> >
> >
>
> As you may be aware, clinical trials with negative outcomes are very rarely published. Some articles worth reviewing are:
>
> Unusual Complications of Deep Brain Stimulation.
> Neurosurg Rev
> DOI 10.1007/s10143-014-0588-9
>
> A Randomized Sham-Controlled Trial of Deep
> Brain Stimulation of the Ventral Capsule/Ventral
> Striatum for Chronic Treatment-Resistant
> Depression
> http://dx.doi.org/10.1016/j.biopsych.2014.11.023
>
> And especially,
> Deep Brain Stimulation for Treatment-resistant Depression:
> Systematic Review of Clinical Outcomes
> (T. Morishita et al)
> Neurotherapeutics
> DOI 10.1007/s13311-014-0282-1
>
> There are many more, but that's a start. What I can tell you is that DBS is significant brain surgery with significant risks. And the benefits are far from certain. Would I do it again? Probably not. But then, I would probably be dead. I figured why not.
>
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1077033
URL: http://www.dr-bob.org/babble/20150223/msgs/1077814.html