Posted by tom2228 on March 17, 2014, at 19:24:38
Seeing new doc in a week and hoping to add a TCA to Marplan, or if she's not cool with that swap Marplan and try the TCA alone.
I was thinking of desipramine because of its least side effects in general, particularly the sedation -- and protriptyline in that sense.
My depression is severe and I'm nervous that if she won't go for the combo that the TCA alone won't be enough, so I was wondering about nortriptyline. What steers me away from its purported effectiveness is the sedation. But I do get pretty agitated when depressed, so it could be somewhat of a good thing if not for the anergia and fatigue I already have from the depression.
That being said, is the nortripyline sedation more calming, or is it more of the heavy, tiring, sleepy, mind-blocking type? Does the energizing aspect of the med overcome the functional-impairing aspect of sedation? Is nortrip, desipramine, or protrip good for anergic bipolar depression?
I find Abilify, which I'm on now, to be particularly bad in causing somnolence and am thinking of asking to decrease or switch to Invega as it's said to be the least sedating AAP. But I wouldn't call Abilify sedating.. just very tiring and making me want to sleep.
The only thing I have to compare as far as sedation is Saphris -- for anyone who's taken both, how does nortrip's compare to Saprhis in this respect. SLS I included you in the subject as I know you've trialed both meds.
^That and Benadryl. A work on google books ranked nortrip as having 4 times the affinity for H1 than diphenhydramine, but that doesn't translate to an overall comparison of how sedating the two meds are.
I know it's all trial and error but I don't want to waste anymore time.
poster:tom2228
thread:1062693
URL: http://www.dr-bob.org/babble/20140307/msgs/1062693.html