Posted by phinxeezaDr on February 9, 2014, at 20:39:42
In reply to nardil tolerance and ensuing cognitive problems, posted by rose45 on April 17, 2013, at 18:35:58
Hi. For what its worth I've been on MAOIs for 10yrs. Started on Nardil. WOW! It was amazing at 1st. I even asked my pdoc if I seemed hypo-manic to him but he simply replied that I had just come outa my box for the 1st time since very early childhood. I was on a high- a natural high. After this faded I still got a lot from Nardil. It made it easier to meet and blend with people esp at work. Then it became less effective and despite several addons it never worked as well as at the start. So I switched MAOIs. Marplan (isocarboxazid) certainly does not have that 'soul changing' effect of Nardil but it is still a very potent antidepressant. It just needs proper dosing, which unfortunately is a lot higher than the txt suggests. I take 90mg whilst the max remains at 60mg. The best thing about it tho is that it can be combined with a lot more meds than Nardil. I also take Seroquel which definitely accentuates my ADs (isocarboxazid, amitriptyline & bupropion). Yes, BUPROPION! Not a rout many docs would would consider going, but its actually quite safe. In fact several NRIs have been shown to protect from Hypertensive Crisis rather than precipitate them.
Basically, try Marplan before taking the plunge with Parnate. I'm very surprised your doc didn't move to Marplan next. You can manipulate Marplan a lot more than the other 2. Also you might do better on a short acting benzo like Xanax which has a short half life meaning less addictive, if taken as needed. Best wishes
poster:phinxeezaDr
thread:1042294
URL: http://www.dr-bob.org/babble/20140123/msgs/1060499.html