Posted by TriedEveryMedication on July 4, 2013, at 23:45:01
My background: attention deficit, that only despiramine seems to help.
Except desipramine makes me anxious, depressed, paranoid, severely angry.
I've tried other TCAs with no luck. I've tried strattera, stims, you name it.
Anyway, back to my question.
I'm looking at the binding affinities for various TCAs (http://en.wikipedia.org/wiki/Tricyclic_antidepressant#Binding_profiles and http://www.crazymeds.us/pmwiki/pmwiki.php/MedClass/TCA#toc4)
I understand from general chem that a lower Ki means stronger affinity.
A stronger affinity means the drug blocks out/inhibits Norepi from binding.
For NET, desipramine has the strongest affinity, so most reuptake inhibition.
But what about the alpha-adrenergic receptors? Norepi signals through these receptors, so you wouldn't want the drug binding to these, right?
Then again, I read that alpha-2 will "suppress the release of norepi via negative feedback". Not sure what that means.
My question: should a good norepi drug have a low NET Ki and a high alpha-adrenergic Ki?
If that's the case, maprotiline might be good to try? (I've tried imipramine, protriptalyne and nortryptaline)
Thank you.
poster:TriedEveryMedication
thread:1046493
URL: http://www.dr-bob.org/babble/20130617/msgs/1046493.html