Posted by tensor on March 13, 2013, at 14:07:58
In reply to Re: Effexor + Mirtazapine MORE effective than PARNATE!, posted by linkadge on March 13, 2013, at 13:41:41
> I think remeron acts more on norepinephrine release than serotonin release.
>
> Its effects on norepinephrine are due to blocking the presynaptic noradrenergic alpha-2 receptors. This promotes norepinephrine release.
>
> I think the serotonin action comes mainly from receptor blockade (5-ht2a/c,5-ht3) which increases the availability at 5-ht1a receptors.
>
> Blocking serotonin 5-ht2a/c receptors also increases catecholamine release in certain brain regions, which might augment the NRI effects of effexor.
>
> Also, remeron can improve sleep, and melatonin release, which might improve receptor sensitivites.
>
> Linkadge
>IMHO, mirtazapine is still the "smartest" psych med. The other newer (not so new anymore) meds are just polished versions of TCAs.
/tensor
poster:tensor
thread:1040126
URL: http://www.dr-bob.org/babble/20130308/msgs/1040219.html