Posted by SLS on February 17, 2013, at 8:42:11
In reply to Borderline Personality Disorder and Neurology., posted by schleprock on February 17, 2013, at 1:11:52
> Does anyone know if there is any kind of neurological basis for BPD? If so, would it have any effect on medication effectiveness, or contribute to treatment resistance?
Your questions are perfectly logical and extremely important. Unfortunately I can't really answer them.
I read recently that there are indeed biomarkers associated with BPD. However, I think there is a confluence of both biological and psychological factors contributing to its etiology. I have seen a combination of Zyprexa and Trileptal work very well for one woman I got to know pretty well. She also profited greatly from CBT. At some point, she had to discontinue the Zyprexa due to excessive weight gain. I don't recall if another AP was eventually chosen for her, but the Trileptal alone seemed to maintain her improvements. That childhood trauma and psychosocial stress might be the causative factors leading to pathological changes in neurodevelopment make BPD no less biological to conceptualize and treat. I am guessing that there is a neurological substrate present from birth that allows for BPD to develop when the brain is stressed by chronic trauma. Some people develop PTSD. Some people develop bipolar disorder. Some people develop OCD. Some people develop GAD. Some people develop BPD. I am guessing that the same history of abuse will lead a different clinical outcomes based upon distinctly different biological vulnerabilities.
- Scott
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Pol Merkur Lekarski. 2011 Oct;31(184):252-5.
[The main directions of research on the causes conditioning the occurrence of the borderline personality disorders].
Ogłodek E, Araszkiewicz A.
Source
Uniwersytet im. Mikołaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy, Katedra Psychiatrii. maxeve@interia.pl
AbstractCurrently, there are two main directions of explaining the occurrence of the borderline personality disorders (BPD). The first of them attempts to explain them upon the constitutional basis, finding the causes in the genetic conditioning, biological and organic factors. The other one underline a role of the psychological developmental categories. A significant role is ascribed to traumatic childhood mental experiences such as: harassment and sexual abuse, as well as neglect of emotional and developmental needs of a child. About 40-71% of the infirm with the borderline personality admits to have been sexually abused. It was observed that there is a connection between the extent of sexual abuse of an individual in childhood and the intensification of the disorders proper for the borderline personality. One should, however, point out that sexual abuse, although they are regarded as a risk factor, are not seen as specific to the infirm with the borderline personality disorders. Moreover, there is a third direction referred to in the literature, seeking the causes of the occurrence of the borderline personality in a significant influence of social-cultural and environment factors. It was noticed that there is a significant correlation between the social situation and the degree of dissemination of those disorders. The borderline personality disorders are more frequent among the people of the low social status background and with relatively low level of education. More and more frequently, theorists and clinical personnel adhere to the view that the development of that disorder is caused by a combination of neurobiological and social factors, together with the pathological qualities of early-childhood development.
PMID:
22097186
[PubMed - indexed for MEDLINE]--------------------------------------
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1038213
URL: http://www.dr-bob.org/babble/20130205/msgs/1038231.html