Posted by joe schmoe on December 11, 2012, at 17:19:29
In reply to Re: How do I lower pro-inflammatory cytokines? » SLS, posted by Trotter on December 11, 2012, at 16:22:18
Reducing systemic inflammation is kind of a large subject but one thing you might want to look into is the role of polyunsaturated fats. From what I have read, the mainstream idea that saturated (animal, and coconut) fats are bad for you is completely backwards. It is actually polyunsaturated fats, which primarily come from unnatural sources like seed oils (so-called "vegetable" oils) which are bad. Unlike saturated fats, which are quite stable, polyunsaturated fats are very easily oxidized either during cooking or in the body. If you eat a lot of polyunsaturated fats, the composition of your LDL reflects this, and you end up with easily oxidized (or already oxidized, especially if high temperature cooking like deep frying was used) small-particle-size LDL, which tends to get between endothelium cells in arteries and cause an inflammation reaction. This reaction attracts macrophages to gobble up the oxidized LDL and become "foam cells", and T cells which secrete....cytokines.
Here's an article on the role of oxidized LDL in coronary diseases:
Atherosclerosis: Evolving Vascular Biology and Clinical Implications: Inflammation in Atherosclerosis and Implications for Therapy
http://circ.ahajournals.org/content/109/23_suppl_1/III-20.full
Like I said it's a large subject and it's mainly the pioneers in research who seem to know what is going on. Everytime I read a mainstream article or food label where the message is to avoid saturated fat and eat more "vegetable oils" I groan, thinking of all those poor people out there whose arteries are clogging up with atherosclerosis as I type this, due to all their consumption of canola oil, soybean oil, peanut oil, fried foods etc.
poster:joe schmoe
thread:1032810
URL: http://www.dr-bob.org/babble/20121130/msgs/1032845.html