Posted by SLS on October 2, 2012, at 12:07:30
In reply to Re: Minocycline update., posted by uncouth on October 2, 2012, at 9:46:46
> Scott how is the minocycline going?
I am still responding well to minocycline. However, I found that I still need prazosin at this point. I had discontinued it, and did not feel as well.
I am now attempting to replace prazosin (half-life = 3 hours) with its sister drug, doxazosin (half-life = 22 hours) in the hope that the timing of dosing won't be so critical and that my libido will not be so greatly reduced. So far, it seems that the doxazosin is inferior, if not inert. Still, I have not lost the improvement produced by minocycline.
> How long did it take before you felt benefits, and at what dose?I began to respond to minocycline by day 5 at a dosage of 100 mg/day. However, I respond better at 200 mg/day.
> I am BP2 too and may ask my doctor about it today...i responded well to memantine at higher doses a few months ago esp for OCD-ish symptoms but my addictive drive has come back and my mood has declined since I stopped cymbalta, which cuased hypomania and weight gain. My primary antidepressant is bupropion which is helping but does not seem to be sufficient at 600mg. I am hoping to finally drop the antipsychotics and mood stabilizers, though. I am still having a terrible time with sleep insomnia and apnea.
What are you currently taking?
Here are two studies you could show your doctor:
http://clinicaltrials.gov/ct2/show/NCT01514422
http://clinicaltrials.gov/ct2/show/NCT01403662
I understand your desire to rid yourself of drugs with side effects. I also understand your desire to take fewer drugs. I hope you can achieve these goals. However, if you find yourself in need of alternatives:
Right now, there is only one drug approved as monotherapy for bipolar depression - Seroquel. The next drug that might be approved for this indication is Latuda.
Have you tried combining Lamictal with Abilify? You might want to consider these two drugs if adding minocycline to bupropion is inadequate. You would want to continue the minocycline while exploring the utility of the combination treatment. You might want to add the Lamictal first and see how you do with it before adding Abilify.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1026350
URL: http://www.dr-bob.org/babble/20121001/msgs/1027309.html