Posted by phidippus on September 29, 2012, at 14:39:43
In reply to Re: Lamictal withdrawal?? » phidippus, posted by sleepygirl2 on September 28, 2012, at 20:18:30
There are few, well-controlled studies of venlafaxine in pregnant women. A study released in May 2010 by the Canadian Medical Association Journal suggests use of venlafaxine doubles the risk of miscarriage
Quetiapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using Seroquel. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Seroquel, do not stop taking it without your doctor's advice.
Klonopin was given a pregnancy Category D rating due to the problems it caused in animal studies. These studies suggested that Klonopin may increase the risk of various birth defects, including cleft palate and limb defects. However, this is a controversial issue, since some human studies have shown that the risk of birth defects may be very small. Benzodiazepines (such as Klonopin) may also cause other problems, such as withdrawal symptoms after an infant is born.
Recently, the North American AED Pregnancy Registry, located at Massachusetts General Hospital in Boston, Massachusetts, found that infants who are exposed to lamotrigine as monotherapy during pregnancy (lamotrigine was used as the only AED by the mother) have a much higher risk of having an oral cleft problem, than infants born to women in a comparison group and who were not exposed to lamotrigine during pregnancy. Oral cleft problems are birth defects that may involve the lip (cleft lip), the palate (cleft palate), or both. During pregnancy, the normal openings between the upper lip and the nose (seen with cleft lip) or between the roof or back of the mouth and the nose (seen in cleft palate) may not close properly. These problems can often be seen with ultrasound testing and can usually be corrected after birth with surgery.
In this study, of 564 women who received lamotrigine alone, 5 instances of isolated cleft lip or palate (not seen as part of any specific syndrome) were seen in the babies. This data gives a prevalence rate of 8.9 per 1000, which means that oral cleft problems may occur in 8.9 of 1000 women treated with lamotrigine monotherapy. This number is 24 times higher than the risk of oral cleft problems seen in babies from the comparison group used in the study.
poster:phidippus
thread:1026600
URL: http://www.dr-bob.org/babble/20120922/msgs/1027024.html