Posted by psychobot5000 on June 28, 2012, at 13:38:21
Hi,
Currently taking a low dose of geodon/ziprasidone: 10mg twice or three times per day. Larger doses are no more effective (but exacerbated OCD). It's been suggested I try to improve my antidepressant response by adding risperidone. I suppose the theory would be that the numbers are a bit better for risperidone on binding affinity for 5HT-2a vs D2 and 5HT-2c (i.e. with risperidone you can get somewhat more 5HT-2a blockage without affecting the other receptors). However, risperidone's effects on the 5ht-1 system are less useful (if I remember correctly, geodon is a 5HT-1a and 1d AGONIST, which, combined with 5ht-2a blocking, may be a good antidepressant combination. Risperidone, in contrast, is a 5-HT-1a blocker).
Anyone have an idea what dose of risperidone might be optimal to get good antidepressant effects out of it in combination with low-dose ziprasidone/geodon? .5mg? .25mg?
Thanks,
PB5000
poster:psychobot5000
thread:1020331
URL: http://www.dr-bob.org/babble/20120608/msgs/1020331.html