Re: How's It Going? » Chairman_MAO

Posted by SLS on November 2, 2011, at 6:20:12

In reply to Re: How's It Going? » SLS, posted by Chairman_MAO on October 31, 2011, at 21:24:57

I thought you might be interested in this. I encountered it quite a few years ago.

- Scott

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http://www.ncbi.nlm.nih.gov/pubmed/7931218
J Neural Transm Suppl. 1994;41:127-34.
Comparisons of the actions of high and low doses of the MAO inhibitor tranylcypromine on 5-HT2 binding sites in rat cortex.
Goodnough DB, Baker GB.
Source
Department of Psychiatry, University of Alberta, Edmonton, Canada.
Abstract
Tranylcypromine (TCP) is a commercially available antidepressant drug, and recent literature reports suggest that high doses of this drug may be particularly effective in treating refractory depression. Down-regulation of 5-HT2 receptors in rat cortex is an effect produced after chronic administration of several antidepressants, and we have conducted a chronic study comparing low- and high-dose TCP in this regard. Male Sprague-Dawley rats were administered TCP (0.5 or 2.5 mg/kg/day) or vehicle (distilled water) via Alzet minipumps implanted subcutaneously in the dorsal thoracic area. Groups of rats were killed 4, 10 or 28 days after pump implantation and whole cortex was dissected out and utilized for preparation of a membrane fraction. Binding studies were performed with this fraction using 3H-ketanserin as the radioligand. Down-regulation (decrease in Bmax) of the 5-HT2 binding site was observed in high-dose animals after 10 and 28 days but not after 4 days. Low-dose TCP had no effect on 5-HT2 densities at any time interval. The affinity of 3H-ketanserin for the 5-HT2 site was not affected by either dose at any time interval. These results suggest that down-regulation of the 5-HT2 site may contribute to the efficacy of high-dose TCP in the treatment of refractory depression.
PMID:
7931218
[PubMed - indexed for MEDLINE]

Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw

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How's It Going? » Chairman_MAO SLS 10/27/11
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