Posted by zatar on July 25, 2011, at 10:24:30
In reply to Re: Has anyone tried Zofran for anxiety/depression?, posted by B2chica on May 17, 2011, at 15:18:12
The 5-HT3 receptor is mentioned as being important in depression and anxiety, but I couldn't find any articles describing it's use in anxiety. I tried it for several weeks to see if it would help my Fibromyalgia symptoms, but did not notice any anti anxiety effects. Of course, dose and duration may not have been optimized.
http://www.ncbi.nlm.nih.gov/pubmed/21342788
Abstract
5-Hydroxytryptamine type 3 (5-HT(3)) receptors are ligand-gated ion channels that play important roles in depression, anxiety, substance abuse, emesis, inflammatory pain, spinal nociception, gastrointestinal function, and cardiovascular reflexes. Probably the most studied modulators of 5-HT(3) receptors are the high affinity competitive 'setron' antagonists typified by ondansetron. However, there exists a broad range of compounds that modulate the 5-HT(3) receptor, not through the orthosteric site but by binding to allosteric sites. Most notable are therapeutic compounds ascribed to certain targets but that allosterically modulate 5-HT(3) receptors at clinically relevant concentrations.
-zatar
poster:zatar
thread:985473
URL: http://www.dr-bob.org/babble/20110714/msgs/991802.html