Posted by mtdewcmu on May 1, 2011, at 16:54:46
In reply to Re: Mirtazapine and blood sugar, posted by desolationrower on May 1, 2011, at 16:21:05
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> no i think the mechanistic evidence is clear. Basically you are creating a situaiton in the body like when you haven't eaten for a while. The increased sympathetic activation releases stored glycose and fat and shifts to fat-burning. Seriously, the stuff is a great drug for increasing fat loss on a diet. Although that isn't to say it is very effective if you are overweight and not restricting calories, although it should increase metanolic rate and reduce hunger a bit, but it does more when you are skinny/excercising, because that is when alpha2 autoreceptors are more improtant.. Whereas antihistamines give you turbomunchies.
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> > The claim that 5-ht2c strongly impacts appetite seems dubious because the effects it would predict, such as SSRIs causing weight-loss, have not proved true. A weight-loss drug that targeted 5-ht2c was recently rejected by the FDA. Evidently the effect was marginal.
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> i wouldn't say its strong, noSo you think the pro-appetite effect of mirtazapine has more to do with the antihistamine effect? I haven't noticed such a potent reaction to other antihistamines. I am impressed with what mirtazapine did to me. I was underweight for my entire adult life prior. But it may have in part coincided with some effect of hitting 30.
poster:mtdewcmu
thread:984165
URL: http://www.dr-bob.org/babble/20110418/msgs/984295.html