Posted by linkadge on August 22, 2010, at 12:39:03
In reply to Re: Cymbalta approved by FDA for chronic pain, posted by simcha on August 21, 2010, at 19:55:35
Some people do well on agents like Cymbalta for pain - especially if the pain is of nonspecific origin or psychosomatic.
However, I think the TCA's have more analgesic effects namely direct opioid receptor interaction, calcium channel blockade and NMDA antagonism.
I do agree with you, that for some people there is a lot of flaking around with agents that don't get to the point for pain. As well, agents like cymbalta are not without dependance potential.
It also depends on the source of the pain too. My father had back pain that was unsucessfully treated with opiates. Ultimatley celabrex provided the best pain relief.
Linkadge
poster:linkadge
thread:959273
URL: http://www.dr-bob.org/babble/20100821/msgs/959393.html