Posted by SLS on May 8, 2010, at 17:38:39
In reply to Re: Questions about tricyclics???, posted by linkadge on May 8, 2010, at 15:43:05
> Who says social anxiety is a result of serotonin deficit?
I'm trying to figure out why 5-HT1a receptor knock-out mice demonstrate increased anxiety. My mind is mush. Also, people with SA have reduced numbers of 5-HT1a receptors, particularly in the amygdala as determined by PET scans. Are these receptors normally inhibitory or excitatory? I would guess that they would be inhibitory if they are heteroreceptors.
It is interesting that 5-HT1a receptor partial agonists are proposed as efficacious in treating anxiety disorders.
- Scott
The measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:946012
URL: http://www.dr-bob.org/babble/20100504/msgs/946797.html