Posted by tonyz on April 20, 2010, at 21:18:50
I've been prescribed Nortrityline and fluvoxamine. I've read that fluvoxamine can raise tricyclics to dangerous levels. I was taking 125mg Nortriptyline and told to start 100mg of fluvoxamine and lower the Nortriptyline to 75mg. I've previously posted about this along with the other meds I'm taking in a separate thread.
I found the following and I'm wondering if someone can interpret this for me. Primarily concerned with the interaction between Nortriptyline and fluvoxamine
* fluvoxamine + imipramine: raised levels of imipramine, quite probably to a degree that will be dangerous. A similar interaction with clomipramine can raise levels to over 1200 mg/l (8).
* fluvoxamine + nortriptyline: safe, but not recommended, because the only CYP450 isoform fluvoxamine does not inhibit is 2D6.
* fluvoxamine + caffeine: definite increase in risk of adverse and possibly toxic effects from caffeine, because of fluvoxamines extraordinarily potent inhibition of CYP450 1A2. This may include cardiac problems, and even possibly increased rates of spontaneous abortion (9-11).
poster:tonyz
thread:944271
URL: http://www.dr-bob.org/babble/20100416/msgs/944271.html