Posted by bulldog2 on April 14, 2010, at 18:06:57
In reply to ultram: from wiki » floatingbridge, posted by floatingbridge on April 14, 2010, at 17:27:05
> Chemistry
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> Characteristics:
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> Structurally, tramadol closely resembles a stripped down version of codeine. Both codeine and tramadol share the 3-methyl ether group, and both compounds are metabolized along the same hepatic pathway and mechanism to the stronger opioid, phenol agonist analogs. For codeine, this is morphine, and for tramadol, it is the M1 metabolite, O-desmethyltramadol. The closest chemical relative of tramadol in clinical use is venlafaxine (Effexor), an SSNRI. The two molecules are nearly identical. Both tramadol and venlafaxine share SSNRI properties, while venlafaxine is devoid of any opioid effects.
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> Comparison with related substances:
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> Structurally, tapentadol is the closest chemical relative of tramadol in clinical use. Tapentadol is also an opioid, but unlike both tramdol and venlafaxine, tapentadol represents only one stereoisomer and is the weaker of the two, in terms of opioid effect. Both tramadol and venlafaxine are racemic mixtures. Structurally, tapentadol also differs from tramadol in being a phenol, and not an ether. Also, both tramadol and venlafaxine incorporate a cyclohexyl moiety, attached directly to the aromatic, while tapentadol lacks this feature. In reality, the closest structural chemical entity to tapentadol in clinical use is the over-the-counter drug phenylephrine. Both share a meta phenol, attached to a straight chain hydrocarbon. In both cases, the hydrocarbon terminates in an amine.
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> Also, Off-Label uses:
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> As an opiate withdrawal management /Anti-Depressant withdrawal aid (proven to be effective, especially with withdrawal from its distant relative Venlafaxine(Effexor).Some p-docs have used this drug off label for depression. This drug does make sense for one that is suffering pain and depression. They also make an extended release version. It's not even scheduled as it can easily be bought online. The problem may be finding a p-doc that will prescribe for depression. Good luck.
poster:bulldog2
thread:943091
URL: http://www.dr-bob.org/babble/20100406/msgs/943408.html