Posted by Brainbeard on April 11, 2010, at 5:56:31
In reply to Re: Zoloft-Anti-Cancer Mechanisms » linkadge, posted by bulldog2 on April 8, 2010, at 16:39:06
> Zoloft has virtually no effect on weight, some action on dopamine, one of the lowest ssri offenders on prolactin
Both studies on which these assumptions are based are flawed for the same reason that most med studies are flawed: they are short-term. In everyday life, sertraline (Zoloft) causes weight gain in the long run just like any other SSRI, although paroxetine (Paxil) is the worst offender. SSRI weight gain often happens in the long term, sometimes only after as long as a year of use has passed.
There is also more than enough evidence that sertraline increases prolactin levels.
Something else: the one SSRI that increases melatonin levels instead of decreasing them is fluvoxamine (Luvox). It does this by severe CYP 1A2 inhibition; this enzyme group is reponsible for the breakdown of melatonin.
poster:Brainbeard
thread:942117
URL: http://www.dr-bob.org/babble/20100406/msgs/943038.html