Posted by bleauberry on February 24, 2010, at 19:33:18
In reply to Re: negative symptoms of schizo... and depression » sigolene, posted by hopefullynow on February 24, 2010, at 15:05:48
I'm sorry I don't have time to go hunt for them right now, but I do recall reading two case reports on pubmed where dopamine agonists (one was bromocriptine, the other carbergoline) were added to amisulpride in order to lower prolactin. In both cases amisulpride continued to work without interference, and prolactin did come down.
While on paper it would appear a dopamine agonist and a dopamine antagonist would counteract each other, I think our understanding of things is too primitive. It just aint that simple. In any case, they did not counteract each other.
Two other reports involved adding abilify to amisulpride. In one case prolactin did come down, the other not. No interruption in amisulpride efficacy.
> > I'm on solian 100 mg / day and dostinex 0.5 mg / week. I dont' know if dostinex counteract solian, because I just began the treatment last week.
>
> Thanks a lot Sigolene,
>
> I am also on Solian (25-50 mg/day) and can't take it much longer due to the elevated prolactin levels, I am bloated, kinda fatty and my breasts are enlarged (I am athletic, no bodybuilder)and besides this puffyness, my libido decreased dramatically to 0.I'll be very pleased if you'd post from time to time how the combo works and if you feel that Dostinex conteracts or not the goods of Solian.
> I'm not sure but solian is an antagonist of D2 dopamine subtype and agonist at D3, Dostinex is an agonist at D2.On papers they counteracts one with the other in D2 subtype.
>
> Thanks a lot for your insight, i'm looking forward for your posts.Be well!
poster:bleauberry
thread:937093
URL: http://www.dr-bob.org/babble/20100216/msgs/937826.html