Posted by bleauberry on January 21, 2010, at 18:07:41
In reply to Re: Surplus of SSRI receptors may lead to TRD, posted by Meltingpot on January 21, 2010, at 16:10:32
> This is interesting but it wouldn't explain why people initially respond to antidepressants and then later on become TRD.
Well, you are correct. The brain is too complicated. It will be decades or longer before we have more advanced wisdom of what is going on here.
Common theories are that whatever neurotransmitter is being enhanced...usually serotonin...the others are slowly drowned out over time...and that somewhere in that adaptation various genes, enzymes, and/or receptors lose their ability to do what they were initially programmed to do. Almost as if they have been deprogrammed.
It also doesn't explain why some people respond very quickly to ADs (I used to) within a matter of days.
Well actually yes it does explain this. The feedback loop doesn't catch on instantly. It takes several days to recognize something has changed and then to switch gears. During that short window, the increased neuros at the synapse can indeed provide a quick blip of feeling much better. As soon as the feedback loop catches on to what is happening, the party is over.
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> I suppose this doesn't explain why all people are have TRD.
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> Denise
poster:bleauberry
thread:934392
URL: http://www.dr-bob.org/babble/20100113/msgs/934594.html