Posted by Brainbeard on January 19, 2010, at 14:27:23
In reply to Re: Prozac dosage questions » Brainbeard, posted by conundrum on January 19, 2010, at 6:07:11
> Im not sure why Stahl believes prozac to be a stronger 5 ht2c antagonist than a reuptake inhibitor. I had found a study that showed the Ki values for prozacs binding sites. It was 60 fairly weak for 5 h2c receptors and 1.6 for the serotonin transporter, much stronger.
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> On the other hand i found that taking 5 mg prozac every other day with a little bit of buspar helped with motivation, but nothing to write home about.The key to understanding why Prozac is a more potent 5HT2C antagonist than an SSRI at low doses, is that for succesful 5HT2C antagonism, you only need little receptor binding, while for serious SRI you need a lot. So you really can't compare the Ki values at an equal par. See one of my posts elsewhere on the board for a more elaborate discussion: http://www.dr-bob.org/babble/neuro/20091104/msgs/931609.html
poster:Brainbeard
thread:904045
URL: http://www.dr-bob.org/babble/20100113/msgs/934370.html