Posted by hopefullynow on November 22, 2009, at 11:44:11
In reply to Re: Treatment resistant OCD » hopefullynow, posted by SLS on November 22, 2009, at 7:13:42
Thanks so much, Scott, interesting...
> Personally, I think the 75mg dosage of Anafranil (clomipramine) used in this study was too low.
I subscribe, at 75 mg/day, you have all the chances to catch only the side effects which are indeed tough, at least in the first month.
> Treatment with Anafranil should be initiated at a dosage of 25 mg daily and gradually increased, as tolerated, to approximately 100 mg during the first 2 weeks. During initial titration, Anafranil should be given in divided doses with meals to reduce gastrointestinal side effects. Thereafter, the dosage may be increased gradually over the next several weeks, up to a maximum of 250 mg daily. After titration, the total daily dose may be given once daily at bedtime to minimize daytime sedation."For me, it's hard to sleep at more than 150 mg given at bedtime.It feels very activating, too activating to sleep, too sedating to take the entire dose in the morning.I'm thinking of combining 100-150 mg of Clomi with 20 mg Prozac, for a punch via 5-HT2C mechanism for an underlying bad anhedonia.What do you think, could be any problems of combining the two regarding their CYP metabolism?
Best regards
poster:hopefullynow
thread:926438
URL: http://www.dr-bob.org/babble/20091117/msgs/926531.html