Posted by SLS on November 19, 2009, at 6:14:08
In reply to eplivanserin (Ciltyri)..., posted by iforgotmypassword on November 19, 2009, at 5:40:25
In case you haven't seen this:
http://jpet.aspetjournals.org/content/317/2/910.full
Was eplivanserin ever studied in humans as an antipsychotic or anxiolytic?
Eplivanserin would be an interesting drug to test as an augmenter of antidepressants. Perhaps it is related to ritanserin. I really don't know. That eplivanserin is an inverse agonist at 5-HT2a receptors might make it more potent than ritanserin. The article I cited indicates that antipsychotics are now shown to be inverse agonists at 5-HT2a rather than antagonists.
* Inverse agonists are sort of like antagonists, but they push the neuronal state in the opposite direction of an agonist.
- Scott
poster:SLS
thread:926203
URL: http://www.dr-bob.org/babble/20091117/msgs/926205.html