Posted by Brainbeard on July 29, 2009, at 15:13:18
In reply to any success with dopaminergic meds?, posted by deprime82 on July 29, 2009, at 7:54:43
Hi,
I have been experimenting with selegiline too, in doses from 2.5 to 10mg. As a stand-alone drug, it sure worsened my obsessive fears. Taking it together with tianeptine, the unique French antidepressant by Servier, really mellowed out the anxiety. Unfortunately, tianeptine isn't prescribed in Holland (nor in the US) and is rather expensive.
I haven't tried a dopamine agonist yet, but I've just received a pack of piribedil tablets - another drug by the French Servier. Piribedil seems to be the most benign dopamine agonist around, but it may be a wild card.
I have theorized my *ss off elsewhere on this forum (http://www.dr-bob.org/babble/neuro/20090701/msgs/904542.html) about 5HT2A-blockade as a way of raising dopamine firing. I'm experimenting with low dose Geodon (5-40mg) right now for this particular effect. I have used Risperdal before on a very low dose, just 0.5mg, and that had a very pronounced dopaminergic effect. Risperdal raises prolactin levels wildly, though, which I don't particularly like.
I do think that 5HT2A-blockade may be one of the milder and more benign ways of stimulating dopamine. It is associated with anxiety relief, after all. Geodon feels a lot harsher than Risperdal, though.
Oh yeah, I've also tried low dose (12.5-50mg) amisulpride, another, lesser known atypical antipsychotic, that in the doserange mentioned 'preferentially blocks dopamine autoreceptors' which for me means a very enjoyable, motivating, libido-raising experience. From what I've read on this forum, this initial effect wanes after several days, while with continued use a milder anti-anxiety and antidepressant effect kicks in after some weeks. I use amisulpride once a week, nowadays (together with modafinil, 50mg and sometimes 2.5-10mg of selegiline, although with the selegiline added my libido begins to take hypomanic forms), because it raises prolactin levels even more wildly than Risperdal.
Theoretically, a dopamine agonist would counter at least some of an atypical antipsychotic's (especially amisulpride and Risperdal) prolactin raising effect.
Hm, and 5HT1A-agonism helps 5HT2A-mediated dopamine boosting, according to Dr. Stahl. That's why I take Buspar along with my Geodon.
Somebody stop me.
poster:Brainbeard
thread:909139
URL: http://www.dr-bob.org/babble/20090721/msgs/909178.html