Posted by SLS on May 28, 2009, at 23:16:03
In reply to Re: Need an alternative to Abilify » SLS, posted by jerrypharmstudent on May 28, 2009, at 20:46:22
> > My vote is for Geodon.
> >
> > If you have already tried Geodon and Seroquel, you might consider getting your hands on amisulpride.
> >
> >
> > - Scott
>
> Do you know Geodon's mechanism of action?It has quite a few. It is the most antidepressant-like of the neuroleptics.
DA2 antagonist ++
DA3 antagonist ++
5-HT1a agonist ++
5-HT1d antagonist
5-HT2a antagonist +++
NE reuptake inhibition
5-HT reuptake inhibition
> Any tough side effects like restlessnessPerhaps some insomnia. I don't think it produces akathisia at the same rate as does Abilify.
> weight gain/etc.?
Geodon is perhaps the only truly weight-neutral atypical neuroleptic. Of the older drugs, I am pretty sure that Stelazine, is weight neutral.
The dosage range for Geodon in the treatment of depression seems to be 40-80mg.
- Scott
poster:SLS
thread:898025
URL: http://www.dr-bob.org/babble/20090524/msgs/898199.html