Posted by iforgotmypassword on May 8, 2009, at 5:05:40
http://www.ncbi.nlm.nih.gov/pubmed/18761383
Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease.
Cansev M, Ulus IH, Wang L, Maher TJ, Wurtman RJ.
Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, Cambridge, MA 02139, USA.Administering uridine-5'-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 days after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may partially restore dopaminergic neurotransmission in this model of Parkinson's disease.
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other studies showed assorted benefits of this combo with choline added.
poster:iforgotmypassword
thread:894745
URL: http://www.dr-bob.org/babble/20090505/msgs/894745.html