Posted by Vincent_QC on January 25, 2009, at 10:45:14
In reply to Making sense of NARDIL 'poop out' (benzo like?), posted by myco on January 23, 2009, at 18:23:21
> Hey
>
> I understand benzos work by playing off gaba receptors to relieve anxiety and muscle tension and suffer from tolerance/"poop out" after sometime. If one of the beneficial effects (and its my hunch this is what I respond so well to) is associated with gaba is it possible that nardil "poop out", that is often experienced, is the effect of tolerance involving gaba? I'm trying to understand this med fully.
>
> thnx
>
>
> atypical depression, gad, social anxiety
> 75mg nardilHi ;-)
Hummm, I think that's not true...I mean, benzo drugs act on gaba of the type A, a more powerfull action than the one who occur with the drugs who act on the gaba-B type.The Nardil act on the gaba-B type, like others anticonvulsives drugs do (Gabapentin, Lyrica...) but I think it's different than the anticonvulsives drugs because the Nardil increase the level of the gaba-B in the brains...the anticonvulsives drugs only block a channel on them but don't increase the number of gaba-B in the brains... Just go on wikipedia website and search for the gaba...they explain it very well...
I don'T think the Nardil stop working because of the tolerance on the gaba-B type of receptors...It's another mystery of life...I don't think that even the Pharmacist or the PDoc or Doctors in research field even know how the AD's drugs works or how the anticonvulsives drugs works also...
One thing is sure, the Gaba-B effect from the Nardil work more well than the Gaba-B effect of anticonvulsives drugs...from my experience....since I try all the anticonvulsives drugs who act on the gaba-B receptors and I never get a relief of my anxiety on them...They do nothing on me...The Nardil had a more calming effect on me...but i'm not sure if it'S the Gaba-B effect or another effect (SE, NE or DA...)...
So the poop-up effect of the Nardil occurying for another reason...maybe like the poop-up of all the others drugs...They all lost some power after a while...PRobably because the brains adapted alone to the effect of the drug...
Too bad i'm not very good in English...sometimes I wish to explain something more well but in English I feel limited...So sorry for this...
poster:Vincent_QC
thread:875681
URL: http://www.dr-bob.org/babble/20090104/msgs/876043.html