Posted by Alucard on December 19, 2008, at 20:07:44
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s » desolationrower, posted by JadeKelly on December 19, 2008, at 18:56:54
There seems to be a lot of back and forth about how much of selegiline's activity is due to MAO-B inhibition and how much is due to its desmethylselegiline and LEVO-amphetamine and LEVO-methamphetamine metabolites (please quit calling it "meth". That's an ignorant slang name even for the substance to which it *actually* refers, DEXTRO-methamphetamine). I've given my two cents on Selegiline in plenty of earlier posts, but I did find something you all might find of value in regards to this question on the web earlier today.
Anybody here heard of a substance called Rasagiline (brand name Azilect)? I read about it a long time ago when it had just been developed by an Israeli pharmaceutical chemist and wasn't yet approved for public use in any Western nation. It has now been approved and can be found from a variety of online retailers (I'm not sure if prescriptions are available directly from US doctors yet but I know it's being prescribed in Europe). The reason I mention this is because Rasagiline selectively inhibits MAO-B (approximately 8-10 times more potently than Selegiline, meaning 1mg of Rasagiline shuts down about as much MAO-B as 10mg of Selegiline) BUT it metabolizes to aminoindan rather than levo-amphetamine & friends. So for those of you who aren't too keen on L-methylamphetamine, etc. floating around in your bloodstream on a daily basis but are still eager for some selective MAO-B inhibition this may be just the thing. It's new and definitely a lot pricier than Selegiline (even factoring in the 10x potency) but it doesn't have any questionable metabolites.
Personally, I'll stick with the liquid selegiline. I like drops better than pills and cheap better than expensive. When I stumble upon a fortune I may change my mind, but I've not discovered anything to convince me that minuscule doses of l-amphetamine or l-methylamphetamine are toxic, especially in the presence of the significant neuroprotective effects of selegeline itself. I am curious about the new MAO-B inhibitor though, so anybody with rasagiline experience please share your experience with us. And anybody with rasagiline AND selegiline experience PRETTY PLEASE post your experience. I'm sure others are curious as well...
poster:Alucard
thread:825078
URL: http://www.dr-bob.org/babble/20081214/msgs/869728.html