Posted by desolationrower on December 16, 2008, at 10:46:42
In reply to Re: Long-Term Users of SSRI's--Need Your Help, posted by crittercuddler on December 16, 2008, at 3:14:02
> I found this too...
>
> Here are some tidbits I have found while researching. Perhaps they can be helpful.
>
> 1.Inositol may reverse desensitization in serotonin receptors. If I understand correctly that is the mechanism behind poop out, right?
>
> Fux M, Levine J, Aviv A, Belmaker RH: Inositol treatment of obsessive
> compulsive disorder. Am J Psychiatry 153:1219-1221, 1996.
>
> "Inositol
> As noted above, there is now considerable evidence that
> pharmacologic manipulation of the serotonergic system may help with OCD
> symptoms. Myo-inositol is a ubiquitous carbohydrate that is present in large
> amounts in brain tissue and is involved in neuronal signaling and
> osmoregulation (Vadnal et al, 1997) and, the phosphatidylinositol cycle is
> the second messenger system for several neurotransmitters, including several
> subtypes of serotonin receptors (Hoyter et al, 1994). In addition,
> desensitization of serotonin receptors is reversed by the addition of
> exogenous inositol (Rahman & Neuman, 1993). There are reports that exogenous
> inositol was effective in controlled trials for patients with depression and
> panic, and recently a research group performed a double-blind, controlled
> crossover trial of 18 grams/day of inositol versus placebo for 6 weeks each
> (Fux et al, 1996). The subjects had significantly lower scores on the YBOCS
> when taking inositol than when taking placebo."
>
> Help anyone?????????????
>
>Its hard to know how inositol is working...its involved in several cell processes, dowstream from several receptors being activated...There was research done into mood stabilizers Lithium, valproate, carbazapine on if they work by depleting inositol...its still an open question.
-d/r
poster:desolationrower
thread:857586
URL: http://www.dr-bob.org/babble/20081214/msgs/869083.html