Posted by azalea on October 3, 2008, at 21:51:25
In reply to Re: What does Depakote ER do to Stimulants?, posted by qbsbrown on October 3, 2008, at 20:41:15
You might find inositol supplementation beneficial for depression and OCD-type symptoms. The studies used 12g inositol daily. This ends up being a lot of pills as most inositol comes in 500mg tablets or capsules. Some health food stores sell inositol powder which make it easier to get the recommended dosage.
Just a thought of something you could try if you haven't already.Eur Neuropsychopharmacol. 1997 May;7(2):147-55.
Controlled trials of inositol in psychiatry.
Levine J.Inositol is a simple polyol precursor in a second messenger system important in the brain. Cerebrospinal fluid inositol has been reported as decreased in depression. A double-blind controlled trial of 12 g daily of inositol in 28 depressed patients for four weeks was performed. Significant overall benefit for inositol compared to placebo was found at week 4 on the Hamilton Depression Scale. No changes were noted in hematology, kidney or liver function. Since many antidepressants are effective in panic disorder, twenty-one patients with panic disorder with or without agoraphobia completed a double-blind, placebo-controlled, four week, random-assignment crossover treatment trial of inositol 12 g per day. Frequency and severity of panic attacks and severity of agoraphobia declined significantly with inositol compared to placebo. Side-effects were minimal. Since serotonin re-uptake inhibitors benefit obsessive compulsive disorder (OCD) and inositol is reported to reverse desensitization of serotonin receptors, thirteen patients with OCD completed a double-blind controlled crossover trial of 18 g inositol or placebo for six weeks each. Inositol significantly reduced scores of OCD symptoms compared with placebo.
> > From the study below, it appears that Depakote (valproate) may have more of a canceling-out effect on stimulants than Lithium. Keep in mind this is only one study. If the combo of Depakote + Dexedrine is working for you, stick with it.
> >
> > Valproate attenuates dextroamphetamine-induced subjective changes more than lithium.
>
> I took my dose of depakote in the morning (cause i sleep terrible when taken at night), along with 5 mg of lexapro, and i had to take more than double my regular dexedrine dose!
>
> Looks like I'll stick to depakote at night, and try 2.5 of lexapro before dropping it. It's tough to give up cause it's making me myself and very social, but is keeping the night time racing thoughts up, and obsessions are worse.
>
> Dexedrine alone, im non social (except online), and I have a hard time leaving the house because it seems my brain wants to hyper focus on one thing. I go all quiet, and thoughts inwards.
>
> Is that normal?
>
> Brian
poster:azalea
thread:854600
URL: http://www.dr-bob.org/babble/20080926/msgs/855644.html