Posted by brot on October 3, 2008, at 13:00:13
In reply to my friends - seroquel .... reverse psychosis, posted by Jeroen on October 3, 2008, at 11:48:34
Dear Jeroen,
I could be wrong but I am wondering about a few things.
the drugs that help you, as you said, are seroquel and abilify. both have a strong serotonergic effect.
One thing i know of what lamictal changes in your brain is that it upregulates serotonin 5ht-1a receptors. as far as I know these receptors regulate the activity of the whole serotonergic system. its an inhibitory receptor. which means lamictal might dampen down your serotonin system. serotonin is also able to inhibit dopamine to some degree. maybe this change still lasts and due to that your dopamine system might be too active. its a known fact that lamictal is one of a few mood stabilisers which can produce psychosis.
well, might work or maybe not, but maybe a ssri will reverse this dysregulation. because as far as i know they downregulate the 5ht-1a receptor, which causes disinhibition of this system. it will counteract the change lamictal causes on that receptors.
If I were you I would give an ssri like escitalopram a try, because its somewhat unlikely to worsen psychosis. tried it yet?
but no garantee.. its far more complex than this.
good luck
poster:brot
thread:855502
URL: http://www.dr-bob.org/babble/20080926/msgs/855522.html