Posted by Bob on September 29, 2008, at 21:33:51
In reply to Re: Exotic Meds for Treatment Resistant Depression » Bob, posted by SLS on September 29, 2008, at 7:46:19
> Hi Bob.
>
> I was first place on a combination of MAOI + TCA in 1983 by the research team at Columbia University. Unfortunately, they were too sheepish to increase the dosage of Nardil beyond 45mg. I responded briefly. Subsequently, another doctor tried Parnate 60mg + desipramine 150mg. It worked.
>
> It took some effort to have my current doctor combine MAOIs and TCAs. This time it would be nortriptyline that I was to use as the TCA. I chose it because it produced a better response when combined with Effexor than did desipramine.I did a little research about MAOI's mixed with tricyclics, and couldn't find anything newer than the early eighties. What is the theory behind why these combinations would be advantageous? A couple articles did mention certain combos that seemed to be quite toxic.
Why did you stop the trial of Effexor with Desipramine?
>
> My switch from Nardil to Parnate was motivated by my not maintaining a full remission with Nardil, although I was still making progress. It was just happening too slowly. I have nothing to lose except for 50 pounds, as long as nortriptyline doesn't put up too much of a fight.
>
Is Parnate weight neutral?
> > One last question... are you able to function sexually on your cocktails?
>
> Yes, although my "performance" has been somewhat diminished, and reaching orgasm difficult. For the times I have been on Nardil, I found that the ability to reach orgasm returns after a few months - even at 90mg.
>
> What dosages of medication are you taking?
I'm on low doses of everything as I've had a history of extreme sensitivity to meds, which was greatly exacerbated by ECT a few years ago. Anyway... Notriptyline 30mg, Citalopram 20mg, Eskalith CR 225mg, and .25mg Risperdal.>
>
> - Scott
poster:Bob
thread:854329
URL: http://www.dr-bob.org/babble/20080926/msgs/854859.html