Posted by Tomatheus on September 27, 2008, at 0:13:32
In reply to Nardil-substitute, posted by Medline on September 26, 2008, at 5:12:21
I agree with Bleauberry. Irreversibly inhibiting the MAO enzymes does more than elevate levels of serotonin, norepinephrine, and dopamine. Irreversibly inhibiting MAO-B decreases the metabolism of phenylethylamine and benzylamine, and irreversibly inhibiting both enzymes reduces the amount of ammonia and hydrogen peroxide that are produced by monoamine oxidization. Inhibiting the reuptake of the monoamines and GABA would elevate the levels of these chemicals from an entirely different mechanism and would likely produce different results. I know from my own experiences that taking reuptake inhibitors has been much different from taking MAOIs, although I never tried combining as many different reuptake inhibitors as you're proposing.
Tomatheus
> Nardil (phenelzine) is considered the single most effective, non-addicting drug for Social Anxiety. It works by elevating levels of Serotonin, Dopamine, Norepinephrine and GABA. I think that combining a Selective Serotonin Reuptake Inhibitor (escitalopram) with a Norepinephrine-Dopamine reuptake inhibitor (Bupropion) and a GABA reuptake inhibitor (tiagabine) might be a modern and safe Nardil-substitute. What do you think?
poster:Tomatheus
thread:854157
URL: http://www.dr-bob.org/babble/20080926/msgs/854311.html