Posted by cumulative on August 10, 2008, at 23:58:27
In reply to Amphetamine neurotoxicity in therapeutic doses, posted by West on August 10, 2008, at 16:22:05
It is my opinion that the changes in dopamine transporters in that study reflect plastic changes, not neurotoxicity. Homeostatic changes in the dopamine transporter (and many other systems -- some of which seem to sensitize) are well-known to occur with dopaminergic psychostimulants, and that study does not show anything different. Also, ever since his hysterical MDMA mess-ups (where it was later found that they accidently used methamphetamine instead of MDMA, later being long after MDMA's neurotoxicity was trumpeted all over the news media) I don't really trust anything coming out of Ricaurte's lab. Other than that study, neurotoxicity from dextroamphetamine (unlike dextromethamphetamine, which has an additional mechanism of neurotoxicity that has a good chance of being active at therapeutic dosing, due to its serotonergic affinity) neurotoxicity is not known to occur at anything near human therapeutic doses of amphetamine.
poster:cumulative
thread:845093
URL: http://www.dr-bob.org/babble/20080805/msgs/845475.html