Posted by SLS on June 17, 2008, at 18:42:59
In reply to Re: Possible Eureka., posted by linkadge on June 17, 2008, at 17:43:31
> But wouldn't an increase in activity at the serotonin transporter lead to an increase in serotonin break down and metabolism?
An increase in the rate of vesicular uptake of neurotransmitter from the cytoplasm by tianeptine (if this should occur) would sequester more neurotransmitter and protect it from the actions of cytoplasmic enzymes such as MAO.
> SSRI's tend to cerebral spinal fluid levels of serotonin breakdown products, it would be interesting to see how tianeptine affects serotonin metabolites.
Yes, it would be very helpful to ascertain this as it would render a clue as to what's happening with 5-HT turnover.
> There may also be some final regulatory activity on the serotonin transporter. SSRI's initially decrease SERT activity, but some studies suggest long term administration upregulates the transporter.
In what way is it upregulated? Is there an increase in the numbers of transporter molecules or is there a functional change in the transporter itself?
- Scott
poster:SLS
thread:835062
URL: http://www.dr-bob.org/babble/20080617/msgs/835144.html