Posted by SLS on June 13, 2008, at 7:16:49
In reply to does selegiline really mitigate DAergic cell loss?, posted by iforgotmypassword on June 13, 2008, at 5:08:48
Hi.
I think Linkadge or Undopaminergic would be the people most capable of answering your question.
I will say this, though. There were studies performed at least 10 years ago refuting the notions that selegiline is an anti-apoptopic (anti-cell death) and anti-oxidant. This contradicts the more recent publications that conclude that selegiline is neuroprotective of dopaminergic neurons. I would tend to give more credence to the later studies because they have the advantage using more technologically advanced investigative equipment and protocols.
One putative anti-oxidant, N-Acetylcysteine (NAC), enhances the production of dopaminergic neurons and may confer a mitigation of apoptosis. It has been demonstrated to be neuroprotective of dopaminergic neurons.
- Scott
poster:SLS
thread:834421
URL: http://www.dr-bob.org/babble/20080606/msgs/834430.html