Posted by undopaminergic on March 19, 2008, at 11:59:26
In reply to Re: Mazindol (Mazinor), Tenuate, Ionomin, Mirapex » Brandon, posted by drugdoc on March 10, 2008, at 9:15:06
> The info posted about Mirapex is ALL wrong. It is a dopamine agonist that is selective for D2/D3 dopamine receptors, not an uptake inhibitor. It is NOT an antiobesity drug (used in Parkinson's disease and RLS). DA agonists have been suggested to have some antidepressant properties, but probably work less well than even currently approved drugs.
>It may depend on the particular type of depression. There is some evidence that pramipexole (Mirapex) is uniquely anti-anhedonic - sometimes too much so... there is an amusing article on compulsive gambling and hypersexuality that appeared in patients shortly after starting pramipexole or dose increases thereof, and then resolved after dose reduction or cessation. To a lesser extent, ropinirole, pergolide and other dopamine agonists were also implicated.
"Pathological Gambling Caused by Drugs Used to Treat Parkinson Disease"
Arch Neurol. 2005;62:1377-1381
(Freely downloadable last time I checked.)
poster:undopaminergic
thread:27486
URL: http://www.dr-bob.org/babble/20080316/msgs/818782.html