Posted by SLS on January 8, 2008, at 6:52:35
In reply to Re: T3 + Remeron » SLS, posted by tensor on January 8, 2008, at 6:10:28
> >T3 produces an increase in the sensitivity of postsynaptic NE receptors. Remeron produces an increase in the release of NE. Maybe they are to be synergistic.
>
> I'm thinking in the same way, despite the lack of studies it might be helpful. It shouldn't necessarily need to be an NRI.Remeron is an antagonist of the presynaptic NE alpha2 autoreceptor, not a reuptake inhibitor. It thus enhances both the synthesis and release of NE. It is an interesting combination.
> This T3/T4 thing is pretty tricky. If your thyroid is functioning well and turning T4 into T3, would it really matter which one you took?
Yes. I am an example of this.
The problem is, I don't know which one to suggest to you. Perhaps the production of T3 is better balanced if T4 is used as the augmenter. Because the stuff I've read about T4 involves bipolar disorder - particularly rapid cycling BD - I would probably try T3 first as it is the drug most closely studied. However, just because T3 was initially chosen to study, does not assure its advantage over T4.
> Which dose of T4 do you found to be most helpful?
Hell if I can remember. Sorry I couldn't be of more help.
- Scott
poster:SLS
thread:805014
URL: http://www.dr-bob.org/babble/20080105/msgs/805021.html