Posted by tecknohed on December 18, 2007, at 7:49:06
In reply to Re: Strange reaction on high-dose antidepressants, posted by amigan on December 18, 2007, at 3:49:27
I also got sedation when I went up on moclobemide. It may have something to do with a particular 5HT receptor, hence why you got it on Prozac too.
Both drugs increase serotonin pretty non-selectively. Maybe at lower doses both drugs increase all serotonin relatively equally, so things are more balanced. But when you increase the dose (of both drugs) one or two particular 5HT receptors (sedating ones) increase thier activity leaving the other receptor sites' activities unchanged, hence increased sedation. Make sense?
I've also found other SSRIs much more sedating than Prozac (paroxetine, citalopram, venlafaxine (low dose)). Perhapse these focus more on the same sedating 5HT sites?
Just a theory.
teck
poster:tecknohed
thread:801263
URL: http://www.dr-bob.org/babble/20071213/msgs/801399.html