Posted by yxibow on November 30, 2007, at 4:05:19
In reply to Re: Invega Warning » yxibow, posted by Zyprexa on November 28, 2007, at 10:42:05
> Please explain. What is a metabolite, is it a modified version. And which is only 50% as effective, the new version? Ie, which is more effective?
>
> ThanksNot 50% as effective, 50% as immediate. When you ingest Risperdal, your body converts it to paliperidone (Invega) and other side metabolites are largely unused psychotropically. So Janssen wanted to keep Risperdal around so they did a me-too (mostly) patent extension and lo and behold paliperidone. There hasn't been a truly "novel" atypical since Abilify and that didn't remove some of the side effects that were predicted.
Well, we're waiting since Thorazine for a TD-free agent and Seroquel is about as close as we've come save for Clozaril which has caveats and has no 100.000% percent guarantees although nobody to date has heard of a journal provable Clozaril-only taker movement syndrome in particular. In fact it improves things often.
I think we'll be waiting another several decades at least, continuing the history for 75 years of antipsychotics. But who knows.
poster:yxibow
thread:796162
URL: http://www.dr-bob.org/babble/20071125/msgs/797772.html