Posted by stargazer2 on June 7, 2007, at 23:56:25
In reply to stargazer2, posted by brooke484 on June 7, 2007, at 20:53:59
Definately take your second dose at bedtime. The pills make me sleepy (don't they you?) so it helps at night to get a really good sleep.
I looked up Plasmin Plus but didn't understand what it is for. What are your side effects?
Mine were the ankle swelling, which is better after a few days and the GI upset, I guess from faster breakdown of the pills from the new formulation which melt in your hands if they get wet so they obviously breakdown alot quicker than the older version.
One other intersting thing I found was that the half life ranged from 1.2 hours to 12 hours but I think the twelve hours was before Pfizer messed with the hard coating on the pill, so I wouldn't be surprised with the shorter half life. I also read something about how once the enzyme is inhibited, then it is not as important to keep the higher dose in your system and a once a day dosing is enough. The rules of half lives and dosing were all over the place ,not consistent at all, so no wonder there are so many opinions on what is best to do, once a day dosing vs. several times a day.
I also read that after a few weeks on a higher dose, you can cut back to 15 or 30 mg and be Ok. Not sure of that either. Pfizer's package insert was no help either, no wonder, they were the ones who messed the original formula up causing chaos for everyone who was stable on it for years. Nice to know the pharmaceutical companies are motivated primarily by greed and profits, not patient care and accountability for consistent products.
Stargazer
poster:stargazer2
thread:760120
URL: http://www.dr-bob.org/babble/20070604/msgs/761780.html